Florence, 1495: Lisa Gherardina and Giuliano from the powerful Medici dinasty are a secret couple. When the Medici family are driven out of town, young Lisa’s father forces her to marry the much older silk merchant, Francesco del Giocondo. But her heart still belongs to her lover.
Venice, 1495: Leonardo da Vinci is the most famous artist of his time. When Giuliano de Medici asks him to paint a portrait of Lisa in order to send messages to his lover, Leonardo joins in this risky game. As a result Lisa not only ends up in dangerous conspiracy but her heart is also sorely tested.